In a small bowl, combine warm water, yeast, and sugar. Let stand for 5-10 minutes until foamy.
In a large bowl, whisk together flour and salt. Add yeast mixture and olive oil. Mix until a shaggy dough forms.
Turn dough out onto a lightly floured surface and knead for 5-7 minutes until smooth and elastic. Place in a lightly oiled bowl, cover, and let rise in a warm place for 1 hour, or until doubled in size.
Preheat oven to 400 degrees F (200 degrees C). Grease a baking sheet.
Punch down the dough and roll it out into a large rectangle (about 12x16 inches) on a lightly floured surface.
Spread pizza sauce evenly over the dough, leaving a small border. Sprinkle with mozzarella cheese, pepperoni, and Parmesan cheese.
Roll up the dough tightly starting from the long side, like a jelly roll. Pinch the seam to seal.
Cut the roll into 8 equal slices.
Place the rolls cut-side up on the prepared baking sheet.
In a small bowl, combine melted butter, garlic powder, and oregano. Brush the tops of the rolls with the butter mixture.
Bake for 15-20 minutes, or until golden brown and cooked through.